Effect on 2.5% solution dextrose on diabetic patient

Questions About PD

Carmen Samonte, Nurse from New Jersey asked
Effect on 2.5% solution dextrose on diabetic patient

2 answers

Nurse, Canada February 23, 2018

We thank you for your question.  A 2.5% PD solution will contain 25 g of dextrose per liter. Therefore a 2 L 2.5% solution will contain 50 g of dextrose. Now, in general, the amount of glucose absorbed by the patient is approximately 50–70% ― depends on short or long dwells (longer dwells, more dextrose absorbed) and type of peritoneal membrane determined by the PET (fast transporter, greater dextrose absorption). Thus, a 2.5% PD solution could contribute anywhere from 25–35 g dextrose per 2 L exchange with CAPD and the absorption and impact on blood sugar will vary depending on the patient.
Please understand that the amount absorbed by a diabetic patient on PD from a 2.5% solution is very individual. For example, other variables such as stress, infection, food intake, medications all impact the changes in blood glucose and response to the dextrose in the solution.
If you have access to a renal dietitian, she or he should well be able to help you manage your patient’s nutritional requirements, taking into account the PD solutions the patient is using each day.”
Zuo X et al. Glucose absorption in nephropathy patients receiving continuous ambulatory peritoneal dialysis. Asia Pac J Clin Nutr 2015; 24(3):394-402.

Doctor (Canada) March 6, 2018

As mentioned in the other response, the higher the concentration of dextrose, the greater the likelihood of glucose absorption systemically. If the patient is frequently requiring 2.5% solutions to maintain UF, one could consider adding icodextrin for one exchange daily as icodextrin will not contribute to hyperglycemia, and it’s ability to optimize UF will allow for use of lower % dextrose solutions for the other exchanges.


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