During one of the sessions of the 12th ISPD congress, it was mentioned that gentamicin ophthalmic solutions are not suitable for exit site prophylaxis because of low gentamicin concentration. I later found that the usual concentration of ophthalmic solutions is 0.3% while that of the cream is 0.1%. Do you think that gentamicin ophthalmic solution is as adequate as gentamicin cream, noting that it is easier to administer?

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Sarra Elamin, Doctor/MD from Sudan asked
During one of the sessions of the 12th ISPD congress, it was mentioned that gentamicin ophthalmic solutions are not suitable for exit site prophylaxis because of low gentamicin concentration. I later found that the usual concentration of ophthalmic solutions is 0.3% while that of the cream is 0.1%. Do you think that gentamicin ophthalmic solution is as adequate as gentamicin cream, noting that it is easier to administer?

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I am the speaker who suggested that opthalmic solutions were in very low concentrations and I stand corrected. Unfortunately, there are no published studies of gentamicin opthalmic solution for exit site prophylaxis, so there is no data to support a protocol using it. I do wonder if a solution, whether 1 or 2 drops, applied to an exit site would not just run off the area, whereas a cream is applied to the skin surface and absorbed just a handcream would be absorbed. Further research would be required to determine if gentamicin opthalmic solution would be as effective as gentamicin cream.

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