Research

NAC Research
Research is supported to address fundamental problems involving PD. Projects involving cooperation amongst sites is encouraged. Request for grants will be announced when funding is available. For further information, please contact Dr. Thomas  Golper, Chair of the Research Committee.

Research Committee Membership:
Chair: Thomas Golper
Mike Flessner
Sharon Nessim
Jeff Perl
Jimmie Pirkle
Francesca Tentori
Eric Wallace

North American Research Consortium in Peritoneal Dialysis (NARC-PD)
At the Nashville NAC meeting in June of 2013 the chapter agreed to form the North American Research Consortium in Peritoneal Dialysis (NARC-PD). The first study is observational and intending to define best catheter placement and early management strategies, under the direction of Rob Quinn and Matt Oliver, with close association with Eric Wallace, Rachel Fissell, Francesco Tentori, and Jeff Perl. This project was selected for its relative ease of performance and to establish the data collection tools/methods needed for a successful transcontinental consortium.
The NAC Research Committee has the duty to first define and prioritize the future scientific studies that NARC will address, and to further enhance its success by recommending organizational and financial considerations. It answers to the NAC Executive Committee/Council.

PDOPPS Initiative
The Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) is designed to advance the understanding of optimal practices for PD patients worldwide and to reduce barriers to PD use. Our hope is that the study will increase the appropriate use of PD, extend technique survival, and improve quality of life for PD patients.
Full details are provided on the home page of the ISPD website. PDOPPS is very relevant to ISPD NAC and NARC. First, PDOPPS is co-ordinated from Ann Arbor, Michigan and many NAC members are very involved. Jeff Perl, a member of our NAC Exec is taking a leadership role in PDOPPS as is Francesca Tentori from Nashville.
Already a number of Canadian sites in Toronto and In London, Ontario are up and going as PDOPPS centers. U.S. sites will soon also join. A number of research questions have been identified.

IMPENDIA published in JASN
CLICK HERE  to read the study
Congratulations to NAC members involved in the IMPENDIA randomized controlled trial, the results of which were published in the November 2013 issue of JASN. Authors include ISPD President and NAC member, Joanne Bargman, Mauro Verrelli from Winnipeg, Bruce Culleton, Ty Shockley and Ken Story from Baxter and a numerous other collaborators. The study is one of the largest randomized trials ever done in the area of PD solutions and, if we include the closely associated EDEN trial, 251 PD patients in 11 different countries were enrolled.
The primary question was whether glucose sparing PD solution regimens comprising icodextrin and amino acids could give improved metabolic outcomes compared to control solutions. The study did show significant benefits in the form of lower glycated hemoglobin and lipid levels but there was an unexpected excess of adverse outcomes related to fluid overload in those receiving the glucose sparing regimen. These findings are certainly going to stimulate discussion.